Ending Chronic Illness

A Revolutionary New Program to Reverse Inflammation and Heal Persistent Disease

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About The Book

A New York Times bestselling doctor guides you through his revolutionary approach to solving the problem of chronic illness by finding what triggers the root cause: multiple sources of inflammation. This approach addresses a wide range of common but challenging conditions including autoimmune diseases, allergies, asthma, chronic pain, long COVID, chronic fatigue, multiple sclerosis, Alzheimer’s disease, autism spectrum disorder, cancer, cardiovascular disease, hormonal dysfunction, mood disorders, and more.

Anyone with a chronic illness knows it can destroy your life. Symptoms for which no doctor can find a cause, or the treatment is worse than the disease itself. Days you are exhausted, wracked with pain, depressed, and so foggy you can’t function, punctuated by days you seem fine. The alarming truth is that while traditional medicine is good at treating most acute illnesses, it has no effective model to address chronic conditions. Richard Horowitz has made it his mission to change that.

For decades, he has been helping to heal thousands of chronically ill patients. Now he brings us his proprietary program based on the Multiple Systemic Infectious Disease Syndrome (MSIDS) Map to identify and treat a wide array of chronic conditions based on new, cutting-edge scientific research. This revolutionary approach provides novel answers for many autoimmune diseases (like multiple sclerosis), allergies, asthma, autism spectrum disorder, Alzheimer’s disease, chronic pain syndromes, long COVID, chronic fatigue syndrome, fibromyalgia, chronic Lyme disease, cancer, cardiovascular disease, GI, hormonal and mood disorders, and more.

At the heart of every chronic condition lies inflammation, but where is it coming from? The 16-point diagnostic map provides clear answers and a treatment program tailored to your specific condition. You’ll find out what tests you might need, with a comprehensive list of lifestyle strategies like how to beat insomnia and reduce stress in as little as five minutes. Dr. Horowitz also takes a deep dive into scientifically proven natural solutions available over the counter, like nutritional supplements, as well as examining the pros and cons of prescription medication, both for short and long term use.

Half of all Americans suffer from chronic illness. Here at last is a plan that works not just to restore their health and vitality but to give them hope for a brighter future.

About The Author

Photograph © Michael Gold

Richard Horowitz is a board-certified MD specializing in internal medicine who is known for his pioneering work with Lyme disease and recognized as one of the country’s foremost experts on chronic illness. Dr. Horowitz is the medical director of the Hudson Valley Healing Arts Center, an integrative medical center, to which more than 13,000 patients have come from all over the US, Mexico, Canada, Europe, Asia, and Australia for treatment. He is the author of two award-winning editions of the New York Times bestseller, Why Can’t I Get Better: Solving the Mystery of Lyme and Chronic Disease, commonly referred to as “The Lyme Bible.” Dr. Horowitz has served as a consultant to governments around the world and dedicated his life to helping those stricken with chronic illness.

Product Details

  • Publisher: Avid Reader Press/Simon & Schuster (October 13, 2026)
  • Length: 640 pages
  • ISBN13: 9781668085318

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Raves and Reviews

“Remarkable new insight.” —Dale Bredesen, MD, New York Times bestselling author The End of Alzheimer’s

"Dr. Horowitz has done what conventional medicine has failed to do—find the root causes of chronic illness and actually fix them. This book is a game-changer for anyone who's been told there are no answers.” —Mark Hyman, MD, #1 New York Times bestselling author and Co-Founder and Chief Medical Officer, Function Health 

"A truly groundbreaking approach. Everyone who suffers from chronic illness needs this book!" —Dr. Will Cole, New York Times bestselling author of Intuitive Fasting

"Dr. Richard Horowitz, who I consider to be one of the foremost experts on the evaluation and treatment of Lyme disease, has now expanded the scope of his observations and has written a brilliant, comprehensive overview of how to understand, diagnose and treat virtually all chronic illnesses. This book is essential reading for anyone with a chronic disease to enable them to get a grasp of all of the complex things happening to their bodies—and provides a step-by-step approach to healing." —Neil Nathan MD, author of Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities and Chronic Environmental Illness and The Sensitive Patient's Healing Guide

"Chronic illness has become an epidemic, and it really can be healed—but only by searching for what actually causes it. Traditional approaches only treat symptoms.  But Richard Horowitz's superb plan is tailored to go to the root of your problem so that you can get your life back!" —Amy Myers, MD, New York Times bestselling author of The Autoimmune Solution

“Dr. Richard Horowitz brilliantly weaves together the science of inflammation, infection, environmental toxicity, immune dysfunction, and personalized healing into a masterclass on chronic illness. A must-read for anyone seeking a more intelligent, effective, and scientifically informed approach.” —Dr. Jill Carnahan, MD, ABIHM, ABoIM, IFMCP, bestselling author of Unexpected: Finding Resilience Through Functional Medicine, Science, and Faith

"At a time when chronic illness is affecting more people than ever and our healthcare system often focuses on managing symptoms rather than uncovering root causes, Dr. Richard Horowitz offers a powerful and much-needed paradigm shift. Ending Chronic Illness helps readers understand the complex factors driving modern disease while providing a practical roadmap toward better health. An invaluable resource." —Michael Karlfeldt, ND, PhD, author of A Better Way to Treat Cancer, Founder, The Karlfeldt Center

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