Actor Joe Manganiello’s gripping memoir of a previously undisclosed health ordeal—marked by multiple near-death experiences and medical crises—that led him beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma, and the deeper histories we carry.

Joe Manganiello seemed to have it all: a soaring career, a new marriage, and what many considered, the best physique in Hollywood. Then, without warning, his body began to fail him. A cascade of autoimmune-related illnesses attacked his skin, thyroid, eyes, lungs, and digestive system, plunging him into a seven year battle, plagued by chronic pain, a life-saving organ amputation, existential crisis, and a prolonged fight for survival that left doctors with few answers and no clear explanation.

As Manganiello struggled to stay alive amidst medicine’s inability to fully explain what ailed him, an unorthodox path emerged—shamans, pagan rituals, ancient myths, long lost family records, and the rebirth of his own spirituality. A search that led him deep into his own bloodline: to a survivor of the Armenian genocide, to ancestors shaped by violence and displacement, and the hidden patterns shared by others living with chronic illness.

In Bloodlines, Manganiello writes with candor and hard-won clarity about illness, inheritance, masculinity, faith, ambition, and the identities we build to endure. More than a memoir of medical crisis, it is a searching account of what happens when the life you have constructed can no longer contain the truth of what you carry.

Deeply personal and emotionally expansive, Bloodlines considers how the past lives on in the body and in the stories we tell about strength, survival, and selfhood. The result is both a page-turning, heart-pounding story for the ages and an essential meditation on inheritance, loss, and the work of living with what remains.