The mighty interstellar hero Astro Mouse and his bright first mate Light Bulb took a wrong turn on their way to the Moon (to see if it was made of cheese), getting lost in space. They go to infinity and beyond trying to find their way home with the help of their adopted, sentient caca. When they land on a planet populated by powdered sugar, the space crew thinks they might just have found their new home. But a quartet of notorious no-goods vacationing there, Skunk Girl, Captain Fastidious, Arkade, and Meduso, calling themselves the Troublesome 4, might just prove problematic for the rodent and appliance super space duo.